The offense starts in a high Horns setup, with both wings at the 45 instead of the corners.
5 sets the ball screen at the top.
3 swings to the opposite corner to create an outnumbered situation on the wing.
The key detail is 4 setting a screen on X2. 4 must loop around to set the screen because X2 will be closing in on the top pick-and-roll and won’t see it coming.
This frees up 2, with X4 forced to make a long closeout.